Journal of Lipid Research, Vol 22, 404-409, Copyright © 1981 by Lipid Research, Inc.
Molecular species of biliary phosphatidylcholines in gallstone patients: the influence of treatment with cholic acid and chenodeoxycholic acid
J Ahlberg, T Curstedt, K Einarsson and J Sjovall
Molecular species of phosphatidylcholines were analyzed in hepatic and
gallbladder bile obtained from six subjects with adenomyoma of the
gallbladder (gallstone-free controls) and 27 gallstone patients undergoing
cholecystectomy. Seven of the gallstone patients had been treated with
cholic acid and seven with chenodeoxycholic acid for at least 8 weeks
before operation. The two predominant species were 1- palmitoyl-2-oleoyl-
and 1-palmitoyl-2-linoleoyl-sn- glycerophosphocholines which together
accounted for 75-80% of the total amount of phosphatidylcholines. Minor
species were 1-palmitoyl-2- palmitoleoyl-, 1-stearoyl-2-linoleoyl-,
1-oleoyl-2-linoleoyl-, and 1-
palmitoyl-2-arachidonoyl-sn-glycerophosphocholines. Gallstone patients had
a higher portion of the 1-palmitoyl-2-oleoyl species and a concomitant
lower proportion of the 1-palmitoyl-2-linoleoyl species than gallstone-free
subjects. The ratio between the two species was about 0.7 and 0.4,
respectively, in the hepatic bile of the two groups of patients. Treatment
with bile acids was associated with a normalization of the pattern of
phosphatidylcholines.
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