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Journal of Lipid Research, Vol 22, 869-871, Copyright © 1981 by Lipid Research, Inc.
ARTICLES |
GH Wirtz and SS Westfall
Vitamin A antibodies were obtained using retinoic acid conjugated to human serum albumin as an immunogen. The following constraints governed the reactivity of vitamin A analogues with such an anti-serum. The stereochemistry of the side chain is relatively unimportant, and 9- and 13-cis retinal react almost as well as all-trans retinal. The nature of the ring is important; all of the compounds that react readily carry a beta-ionic ring; all of the compounds bearing an aromatic ring react poorly; the two compounds that display intermediate reactivity have non- aromatic 6- and 5-membered rings, respectively.
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