Journal of Lipid Research, Vol 22, 899-904, Copyright © 1981 by Lipid Research, Inc.
Cellular retinoid-binding proteins in reginerating rat liver: demonstration of a novel cellular retinoid-binding protein
M Omori, Y Muto and T Nagao
Changes in the levels of liver cellular aetinol- and retinoic acid- binding
proteins were studied after partial (about 70%) hepatectomy for 14 days in
the rat. It was found that a novel binding protein designated F-type
appears transiently in liver cytosol 3 days after the operation. The
appearance of this protein coincides with the peak level of the alpha
1-fetoproteain. In contrast, cellular retinoic acid- binding protein was
detected only the first day after hepatectomy, whereas no significant
change was observed in the level of the cellular retinol-binding protein
during the entire observation period. [3H]Retinol or [3H]retinoic acid
complexed with serum retinol-binding protein injected intravenously into
vitamin A-deficient rats 1 day after the hepatectomy was recovered 5 min or
20 min later bound specifically to cellular retinol- or retinoic
acid-binding protein, respectively. The results presented here strongly
suggest that each of the three cellular retinoid-binding proteins plays a
distinct role in cell proliferation and differentiation.
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