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Journal of Lipid Research, Vol 22, 1131-1141, Copyright © 1981 by Lipid Research, Inc.
AM Fogelman, ME Haberland, J Seager, M Hokom and PA Edwards
Improved techniques of cell isolation resulted in 90 to 100 million
monocytes from a single donor. Addition of low density lipoprotein (LDL) to
to cultures of these cells resulted in the down regulation of LDL receptor
activity. Addition of malondialdehyde-altered LDL. which enters the cell
through a receptor for negatively charged proteins (the scavenger
receptor), produced an even greater down regulation of the LDL receptor,
indicating that both receptors are present on the same cell. Within hours
of adherence of the cells, there was a dramatic decrease in the activity of
both receptors. LDL receptor activity was highest during the first week in
culture and then declined, despite the maintenance of a constant LDL
concentration in the medium. Scavenger receptor activity surpassed LDL
receptor activity by the 6th day and was maximally expressed during the
second week. Increasing cell density resulted in a slight increase in the
activity of the LDL receptor and a dramatic increase in scavenger receptor
activity. Insulin had no significant effect on either receptor. Removing
serum from the culture medium for 48 hr resulted in a 3.5-fold increase in
LDL receptor activity and a 2-fold decrease in scavenger receptor activity.
Twenty- four hr after the cells were re-exposed to serum, the activities of
both receptors essentially returned to base line. Heat-inactivation of
serum was associated with an increased cholesteryl ester content of the
cells and depressed receptor activities. Scavenger receptor activity
appears related to the maturation of monocytes into macrophages and is
promoted by increasing cell density and serum factors that are heat labile.
ARTICLES
Factors regulating the activities of the low density lipoprotein receptor and the scavenger receptor on human monocyte-macrophages
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