Journal of Lipid Research, Vol 22, 1174-1180, Copyright © 1981 by Lipid Research, Inc.
On determining the extent of side-pool synthesis in a three-pool model for whole body cholesterol kinetics
R Ramakrishnan, RB Dell and DS Goodman
Whole body cholesterol turnover is well described by a three-pool model.
This model has eight unknown parameters: three masses, three synthesis
rates, and two intercompartmental exchange rates. Only six parameters can
be estimated by fitting the model to the plasma specific radioactivity-time
curve which results from the intravenous injection of labeled cholesterol.
Additional information is obtained if a precursor of cholesterol, labeled
with a different isotope, is also injected. Equations are derived to enable
the calculation of all eight model parameters from the two
sum-of-exponentials equations that are fitted to the two tracer curves. The
characteristics of a satisfactory precursor are discussed.
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