Journal of Lipid Research, Vol 22, 1247-1253, Copyright © 1981 by Lipid Research, Inc.
Effects of hypocholesterolemia and chronic hormonal stimulation on sterol and steroid metabolism in a Leydig cell tumor
M Ascoli
The studies presented herein were done to investigate the effects of
drug-induced hypocholesterolemia and chronic hormonal stimulation on
cholesterol metabolism and steroid biosynthesis in a functional Leydig cell
tumor. It was found that 4-aminopyrazolo(3,4-d)-pyrimidine (4-APP)- induced
hypocholesterolemia had no effect on a) the amount of cholesterol present
in the tumor, b) cholesterol biosynthesis, and c) steroid production.
Chronic stimulation with choriogonadotropin also had no effect on the
amount of cholesterol present in the tumor, but it increased steroid
production and cholesterol biosynthesis. These results suggest that the
Leydig tumor cells primarily use intracellular cholesterol for steroid
biosynthesis. Other data show that 4-APP treatment reduces gonadotropin
binding in the Leydig tumor cells.
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati What's this?
