HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Cole, T. G. Articles by Heimberg, M. Search for Related Content PubMed PubMed Citation Articles by Cole, T. G. Articles by Heimberg, M. Social Bookmarking                      What's this?

Journal of Lipid Research, Vol. 23, 81-91, January 1982
Copyright © 1982 by Lipid Research, Inc.

Effects of adrenalectomy and dexamethasone on hepatic lipid metabolism

Thomas G. Cole , Henry G. Wilcox , and Murray Heimberg

Department of Pharmacology, University of Missouri School of Medicine, Columbia, MO 65212

The influence of adrenalectomy and dexamethasone on hepatic free fatty acid metabolism was studied in isolated perfused livers from male rats. Adrenalectomy 1 week prior to perfusion did not affect uptake of oleate, output of triglyceride, or rate of ketogenesis compared to sham-operated match-fed controls. Livers from dexamethasone-treated rats (0-2 mg/kg per day for 7 days) removed less oleate from the perfusate, esterified more to total and very low density lipoprotein (VLDL) triglyceride, and oxidized less to ketone bodies, compared to match fed controls; additional studies with [1-¹⁴C]oleate confirmed these findings. The output of glucose by livers from dexamethasone-treated rats was also stimulated. The output of VLDL triglyceride was correlated with output of total perfusate triglyceride (r = 0.77, P < 0.001). Prior to perfusion, dexamethasone livers accumulated more triglyceride than did control livers. Adrenalectomy did not affect the concentration of plasma free fatty acid or blood ketones and glucose; however, the plasma concentration of triglyceride was elevated. Dexamethasone increased the concentration of plasma free fatty acid, total triglyceride, and VLDL protein, triglyceride, phospholipid, and free cholesterol. No changes were observed in the concentration or composition of plasma low density lipoprotein (LDL) lipids. The concentration of plasma high density lipoprotein (HDL) protein and lipid, and plasma apoA-I, tended to increase; the ratio of total HDL cholesterol to LDL cholesterol was elevated with dexamethasone treatment. These observations suggest that augmented synthesis and secretion of VLDL triglyceride contribute to glucocorticoid-induced hyper-triglyceridemia.—Cole, T. G., H. G. Wilcox, and M. Heimberg. Effects of adrenalectomy and dexamethasone on hepatic lipid metabolism.

Supplementary key words VLDL • LDL • HDL • lipoprotein lipase

Submitted on March 21, 1980
Revised on July 21, 1981

CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this?

This article has been cited by other articles:

				S. C. Rathman, B. Lewis, and R. J. McMahon Acute glucocorticoid treatment increases urinary biotin excretion and serum biotin Am J Physiol Endocrinol Metab, March 1, 2002; 282(3): E643 - E649. [Abstract] [Full Text] [PDF]

				S. B. Amin, R. A. Sinkin, M. P. McDermott, and J. W. Kendig Lipid Intolerance in Neonates Receiving Dexamethasone for Bronchopulmonary Dysplasia Arch Pediatr Adolesc Med, August 1, 1999; 153(8): 795 - 800. [Abstract] [Full Text] [PDF]

				C.-N. Wang, R. S. McLeod, Z. Yao, and D. N. Brindley Effects of Dexamethasone on the Synthesis, Degradation, and Secretion of Apolipoprotein B in Cultured Rat Hepatocytes Arterioscler. Thromb. Vasc. Biol., September 1, 1995; 15(9): 1481 - 1491. [Abstract] [Full Text]