J. Lipid Res. Neurobiology of Lipids (ISSN1683-5506)
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Journal of Lipid Research, Vol 23, 456-465, Copyright © 1982 by Lipid Research, Inc.

ARTICLES

Structure of the side chain of the C29 dicarboxylic bile acid occurring in infants with coprostanic acidemia

G Janssen, S Toppet and G Parmentier

The structure of the side chain of the 3 alpha, 7 alpha, 12 alpha- trihydroxy-5 beta-C29 dicarboxylic bile acid occurring in body fluids of infants with coprostanic acidemia was investigated by means of mass spectrometry and nuclear magnetic resonance spectroscopy. The findings identified this bile acid as 3 alpha, 7 alpha, 12 alpha-trihydroxy-27a, 27b-dihomo-5 beta-cholestane-26,27b-dioic acid (3 alpha, 7 alpha, 12 alpha-trihydroxy-27-carboxymethyl-5 beta-cholestan-26-oic acid).
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Copyright © 1982 by the American Society for Biochemistry and Molecular Biology.