Journal of Lipid Research, Vol 23, 720-725, Copyright © 1982 by Lipid Research, Inc.
Lipid class analysis of the central nervous system of myelin-deficient Wistar rats
CK Csiza
Brains and spinal cords of myelin-deficient (md) and littermate control
rats were analyzed serially for myelin lipids during the period from 13 to
32 days of age. The glycolipids of md rat brains were severely reduced and
remained so during the period of study; brain cholesterol and phospholipids
increased moderately but never reached the values for control brains.
Deficiency of all three lipid classes was marked in the spinal cord and did
not change with age. Among the glycolipids of md rats, deficiency was more
severe in cerebrosides than sulfatides. The pronounced reduction of
cerebrosides in the early stages of myelination suggests that abnormal
synthesis of these glycolipids may be the most important biochemical
anomaly responsible for myelin deficiency.-- Csiza, C.K. Lipid class
analysis of the central nervous system of myelin-deficient Wistar rats.
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