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Journal of Lipid Research, Vol. 23, 850-862, August 1982
Molecular Disease Branch, National Heart, Lung, and Blood Institute, Department of Nuclear Medicine, The Clinical Center, National Institutes of Health, Bethesda, MD 20205, and Donner Laboratory, Lawrence Berkeley Laboratory, University of California, Berkeley, CA 94720
The kinetics of the major apolipoproteins (apo) of plasma high density lipoproteins (HDL), apoA-I and apoA-II, were examined in a total of 44 individual tracer studies in 22 normal male and female subjects. Following the intravenous injection of radioiodinated HDL, the specific radioactivity decay of apoA-I within HDL (residence time, 5.07 ± 1.53 days), as determined by column chromatography, was significantly (P < 0.01) faster than that of apoA-II (residence time, 5.96 ± 1.84 days). The specific radioactivity decay of apoA-I within HDL when labeled on HDL or as apoA-I was found to be almost identical. Similar results were obtained for apoA-II. Analysis of simultaneous paired radiolabeled apoA-I and apoA-II studies revealed that the mean apoA-I plasma residence time (4.46 ± 1.04 days) was significantly (P < 0.01) shorter than that for apoA-II (4.97 ± 1.06 days). Females had significantly (P < 0.01) higher apoA-I plasma concentrations (124 ± 24 mg/dl) and apoA-I synthesis rates (13.58 ± 2.23 mg/kg · day) than did males (108 ± 16 mg/dl, and 11.12 ± 1.92 mg/kg · day, respectively). Plasma apoA-I levels were correlated with plasma apoA-I residence times, but not synthesis rates; and apoA-II concentrations were correlated only with apoA-II whole body residence times. ApoA-I and apoA-II plasma residence times were inversely correlated with plasma triglyceride levels. These data are consistent with the following concepts: 1) labeling of apoA-I and apoA-II as apolipoproteins or on HDL does not affect their specific radioactivity decay within HDL; 2) the mean residence time of apoA-I both in plasma and in HDL is significantly shorter than that of apoA-II; 3) the increased apoA-I levels seen in female subjects are due to increased apoA-I synthesis; and 4) the plasma apoA-I residence time, which is inversely correlated with plasma triglyceride levels, is an important determinant of apoA-I concentration in both males and females.—Schaefer, E. J., L. A. Zech, L. L. Jenkins, T. J. Bronzert, E. A. Rubalcaba, F. T. Lindgren, R. L. Aamodt, and H. B. Brewer, Jr. Human apolipoprotein A-I and A-II metabolism. Supplementary key words apoA-I and apoA-II residence times and synthesis rates • plasma triglycerides
Submitted on September 24, 1981
Copyright © 1982 by Lipid Research, Inc.
Human apolipoprotein A-I and A-II metabolism
Revised on March 10, 1982
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