| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Journal of Lipid Research, Vol 24, 1304-1309, Copyright © 1983 by Lipid Research, Inc.
ARTICLES |
AL Esterman, H Baum, NB Javitt and GJ Darlington
The effect of 26-hydroxycholesterol and other intermediates in bile acid synthesis on HMG-CoA reductase activity was studied in Chinese hamster ovary (CHO) cell culture. Incubation of CHO cells for 5 hr in 0.25 microM 26-hydroxycholesterol caused a 40% inhibition of HMG-CoA reductase activity. All other intermediates tested including 3 beta- hydroxy-5-cholenoic acid and cholest-5-ene-3 beta,7 alpha,26-triol, oxidation products of 26-hydroxycholesterol, had little or no inhibitory effect. It is proposed that 26-hydroxycholesterol has a selective biological role in the regulation of cholesterol synthesis.
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati What's this?
This article has been cited by other articles:
|
|
 |
|
  A. Frolov, S. E. Zielinski, J. R. Crowley, N. Dudley-Rucker, J. E. Schaffer, and D. S. Ory NPC1 and NPC2 Regulate Cellular Cholesterol Homeostasis through Generation of Low Density Lipoprotein Cholesterol-derived Oxysterols J. Biol. Chem., July 3, 2003; 278(28): 25517 - 25525. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Escher, Z. Krozowski, K. D. Croft, and D. Sviridov Expression of Sterol 27-Hydroxylase (CYP27A1) Enhances Cholesterol Efflux J. Biol. Chem., March 21, 2003; 278(13): 11015 - 11019. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Meir, D. Kitsberg, I. Alkalay, F. Szafer, H. Rosen, S. Shpitzen, L. B. Avi, B. Staels, C. Fievet, V. Meiner, et al. Human Sterol 27-Hydroxylase (CYP27) Overexpressor Transgenic Mouse Model. EVIDENCE AGAINST 27-HYDROXYCHOLESTEROL AS A CRITICAL REGULATOR OF CHOLESTEROL HOMEOSTASIS J. Biol. Chem., September 6, 2002; 277(37): 34036 - 34041. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. B. Javitt 25R,26-Hydroxycholesterol revisited: synthesis, metabolism, and biologic roles J. Lipid Res., May 1, 2002; 43(5): 665 - 670. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. B. Reiss, N. W. Awadallah, S. Malhotra, M. C. Montesinos, E. S. L. Chan, N. B. Javitt, and B. N. Cronstein Immune complexes and IFN-{gamma} decrease cholesterol 27-hydroxylase in human arterial endothelium and macrophages J. Lipid Res., November 1, 2001; 42(11): 1913 - 1922. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Férézou, M. Combettes-Souverain, M. Souidi, J. L. Smith, N. Boehler, F. Milliat, E. Eckhardt, G. Blanchard, M. Riottot, C. Sérougne, et al. Cholesterol, bile acid, and lipoprotein metabolism in two strains of hamster, one resistant, the other sensitive (LPN) to sucrose-induced cholelithiasis J. Lipid Res., December 1, 2000; 41(12): 2042 - 2054. [Abstract] [Full Text]
|
|
|
|
 |
|
 G. J. Schroepfer Jr. Oxysterols: Modulators of Cholesterol Metabolism and Other Processes Physiol Rev, January 1, 2000; 80(1): 361 - 554. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. J. Repa, E. G. Lund, J. D. Horton, E. Leitersdorf, D. W. Russell, J. M. Dietschy, and S. D. Turley Disruption of the Sterol 27-Hydroxylase Gene in Mice Results in Hepatomegaly and Hypertriglyceridemia. REVERSAL BY CHOLIC ACID FEEDING J. Biol. Chem., December 8, 2000; 275(50): 39685 - 39692. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| All ASBMB Journals | Journal of Biological Chemistry |
| Molecular and Cellular Proteomics | ASBMB Today |
