Journal of Lipid Research, Vol 24, 1468-1474, Copyright © 1983 by Lipid Research, Inc.
The minor bile acids of the toad, Bufo vulgaris formosus
M Une, T Kuramoto and T Hoshita
Bile from the toad, Bufo vulgaris formosus, was found to contain a number
of minor bile acids along with two major bile acids, 3 alpha, 7 alpha, 12
alpha-trihydroxy-5 beta-cholest-22-ene-24-carboxylic acid and 3 alpha, 7
alpha, 12 alpha-trihydroxy-5 beta-cholest-23-en-26-oic acid. The following
minor bile acids were identified by combined gas-liquid chromatography-mass
spectrometry: cholic acid, allocholic acid, 3 alpha, 7 alpha, 12
alpha-trihydroxy-5 beta-cholestan-26-oic acid, 3 alpha, 7 alpha, 12
alpha-trihydroxy-5 alpha-cholestan-26-oic acid, 3 alpha, 7 alpha, 12
alpha-trihydroxy-5 alpha-cholest-22-ene-24- carboxylic acid, 3 alpha, 7
alpha, 12 alpha-trihydroxy-5 alpha-cholest- 23-en-26-oic acid, varanic
acid, and 3 alpha, 7 alpha, 12 alpha, 24- tetrahydroxy-24-methyl-5
beta-cholestan-26-oic acid. The fact that the toad bile contains not only
cholic acid but also 3 alpha, 7 alpha, 12 alpha-trihydroxy- and 3 alpha, 7
alpha, 12 alpha,24-tetrahydroxy-5 beta- cholestan-26-oic acids, which have
been recognized as biosynthetic intermediates of cholic acid in mammals,
suggests that the toad is capable of synthesizing cholic acid by the same
pathway as that for the biosynthesis of the C24 bile acid in mammals.
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