Journal of Lipid Research, Vol 24, 491-511, Copyright © 1983 by Lipid Research, Inc.
The quantitative estimation of bile acids and their conjugates in human biological fluids
JM Street, DJ Trafford and HL Makin
This review attempts to provide a concise and critical summary of modern
methods for the analysis of bile acids and their conjugates in human
biological fluids. Most emphasis is given to more up-to-date procedures
that have been applied to the study of human disease and attention is drawn
to previous reviews in areas that have not been covered here. An increasing
awareness of the possibility that bile acids may be involved in the
etiology of a number of disorders, or that such disorders may give rise to
changes in bile acid concentration, has stimulated the study of bile acid
methodology. Although many procedures have been described using, for
example, high-pressure liquid chromatography (HPLC), gas-liquid
chromatography (GLC), gas-liquid chromatography--mass spectrometry
(GLC-MS), and radioimmunoassay (RIA), no simple but comprehensive procedure
for the estimation of bile acids and their conjugates has yet been
published. Further study in this area is still required in order to
establish the role of bile acid estimations in the routine diagnosis and
treatment of disease.
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