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Journal of Lipid Research, Vol 24, 604-613, Copyright © 1983 by Lipid Research, Inc.
E Sacquet, M Parquet, M Riottot, A Raizman, P Jarrige, C Huguet and R Infante
Five patients fitted with a biliary T-tube after cholecystectomy were given
orally a tracer dose of [14C]hyodeoxycholic acid and 500 mg of the same
unlabeled acid. Intestinal absorption and biotransformation, liver
metabolism, bile secretion, fecal and urinary excretions of this acid or of
its metabolites were studied. Hyodeoxycholic acid was well absorbed by the
human intestine. It was not subjected to intestinal transformations and,
particularly, did not produce a significant amount of lithocholic acid,
which does not support the existence of intestinal bacterial 6
alpha-dehydroxylases. The percentage of hyodeoxycholic acid and of its
metabolites recovered in bile varied from 11.5 to 31%. Two major
metabolites were isolated from bile: glycohyodeoxycholic acid and
hyodeoxycholic acid glucuronide. Analysis of urinary bile acids showed that
a large proportion (30-84%) of the administered hyodeoxycholic acid was
excreted by the kidney as a glucuronide. The large extent of both
glucuronidation and urinary excretion of hyodeoxycholic acid is a unique
example of bile acid metabolism and excretion in man.
ARTICLES
Intestinal absorption, excretion, and biotransformation of hyodeoxycholic acid in man
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