Journal of Lipid Research, Vol 24, 746-752, Copyright © 1983 by Lipid Research, Inc.
Dietary fiber decreases cholesterol and phospholipid synthesis in rat intestine
SE Schwartz, C Starr, S Bachman and PG Holtzapple
The effects of fiber ingestion on the incorporation of oleic acid into
triglyceride and lecithin, acetate incorporation into cholesterol, and
monosaccharide and amino acid transport were determined in rat intestine.
Prolonged pectin (10% by weight) ingestion caused a decrease in jejunal and
ileal cholesterol synthesis (33% and 52%, respectively). Pectin ingestion
reduced cholesterol synthesis by 60% in ileal crypt cells, but did not
affect cholesterol synthesis in the jejunal or ileal villus cells or in
jejunal crypt cells. Cholesterol synthesis in isolated crypt cells was
markedly less than in isolated villus cells. Prolonged ingestion of a
fiber-free diet supplemented with either cellulose or pectin (10% and 5% by
weight, respectively) decreased jejunal lecithin glucose and leucine
absorption but did not affect jejunal triglyceride synthesis.
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati What's this?
