Journal of Lipid Research, Vol 24, 930-937, Copyright © 1983 by Lipid Research, Inc.
Differential susceptibility of mono- and di-O-alkyl ether phosphoglycerides to acetolysis
R Kumar, ST Weintraub and DJ Hanahan
The effectiveness of acetolysis as a tool in structural characterization of
mono- and di-O-alkyl phosphoglycerides was investigated. Surprisingly, it
was found that the di-O-alkyl phosphoglycerides were resistant to attack
during acetolysis, whereas the mono-ether types, with a free hydroxyl
function or an ester on carbon-2, were easily attacked at the
glycerol-phosphate bond. On the other hand, Vitride reduction occurred
readily with the mono-ether or di-ether phosphoglycerides. The implications
of these findings as they relate to identification of ether phospholipids
in tissues are discussed.
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