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Journal of Lipid Research, Vol 25, 97-110, Copyright © 1984 by Lipid Research, Inc.
BR Krause and AD Hartman
Adipose tissue in man is a major site for cholesterol storage. In obesity
over half of total body cholesterol may reside within this tissue; however,
relatively little attention has been directed toward understanding the
cholesterol metabolism and its relationship to whole body cholesterol
homeostasis in this tissue. In this review the factors which influence
cholesterol storage are discussed, with particular emphasis on the effects
of diet and drug treatment in both animals and man. The uptake, synthesis,
and mobilization of adipose tissue cholesterol appears to be mediated
and/or regulated, as in other tissues, by the plasma lipoproteins, and
these processes are examined with regard to both normal and pathologic
states.
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Adipose tissue and cholesterol metabolism
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