Journal of Lipid Research, Vol 25, 428-436, Copyright © 1984 by Lipid Research, Inc.
The economy of the enterohepatic circulation of bile acids in the baboon. 1. Studies of controlled enterohepatic circulation of bile acids
RN Redinger, JW Hawkins and DM Grace
A primate model with controlled enterohepatic circulation has been
developed which allowed short-term evaluation of bile salt pool size,
cycling frequency, and fecal losses. We found that when bile salt secretion
into the small bowel was increased above 700 mumol/hr bile acid pool
cycling frequency was also increased. The latter allowed short-term
regulation of bile salt pool size by affecting increased fecal losses.
These compensatory mechanisms were associated with a return of bile acid
secretion and cycling frequency to normal usually within 12-24 hours.
Conversely, during decreased bile salt secretion, regulation of bile salt
pool size was accomplished by decreased pool cycling, which decreased fecal
losses. Bile acid secretion into the intestine was therefore a major
determinant of bile salt cycling frequency. The latter affected bile salt
fecal loss to provide short- term regulation of bile salt pool when
feedback regulation of bile salt synthesis was nonoperative.
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