Journal of Lipid Research, Vol 25, 678-683, Copyright © 1984 by Lipid Research, Inc.
Diphosphatidylglycerol in experimental acute alveolar injury in the dog
DF Liau, CR Barrett, AL Bell, G Cernansky and SF Ryan
Acute alveolar injury closely resembling that seen in humans was induced in
dogs by subcutaneous injection of N-nitroso-N- methylurethane. Necrosis of
alveolar epithelial cells was observed during early injury. Proliferation
of immature epithelial cells which began during early injury and became
massive after peak injury was followed by their differentiation to mature
type II cells during recovery. Quantities of diphosphatidylglycerol (DPG)
and of phosphatidylglycerol (PG) in alveolar lavage and in post-lavage lung
tissue were measured. An increase in tissue DPG coincided with a sharp
decrease in tissue and lavage PG during early injury. DPG was not
detectable in the lavage. During late recovery, tissue DPG increased
threefold over controls. This increase was accompanied by persistence of a
50% decrease in tissue PG and 83% decrease in lavage PG. Biosynthesis of
DPG and PG in isolated lung mitochondria demonstrated that DPG was formed
from PG in the presence of CDP-diglyceride. These findings suggest that the
low level of PG in the surfactant complex during acute alveolar injury is
due to increased turnover of PG to DPG in the lung.
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