Journal of Lipid Research, Vol 25, 851-856, Copyright © 1984 by Lipid Research, Inc.
Conformation and packing of unsaturated chains in crystals of cholesteryl nervonate at 123 K
P Sawzik and BM Craven
At 123 K, cholesterol cis-15-tetracosenoate (cholesteryl nervonate,
C51H90O2) is monoclinic, space group P2(1) with a = 12.948(5), b =
8.805(5), c = 42.98(5) A, beta = 105.93(3) degrees, [lambda(CuK alpha) =
1.5418 A], having two independent molecules (A) and (B) in the unit cell.
The crystal structure at 123 K has been determined from 6329 reflections
with sin theta/lambda less than 0.54 A-1, of which 1990 gave I greater than
2 sigma(I). Structure refinement by Fourier methods and block diagonal
least squares gave R = 0.232 for all reflections, R = 0.135 for those with
I greater than 2 sigma(I). The crystal structure consists of layers in
which there is close packing of cholesteryl groups and the proximal
segments of the ester chains. This layer structure occurs also in
cholesteryl palmitoleate and the alkanoate esters C9 through C12. Because
the nervonate chains are longer, they become aligned in the interface
region between layers, but without a regular subcell structure being
established. The nervonate (A)-chain is almost extended, while the
(B)-chain has two bends, one in the saturated region. Both chains have
complex dislocations at the cis- double bond.
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