Journal of Lipid Research, Vol 26, 115-126, Copyright © 1985 by Lipid Research, Inc.
Low density lipoprotein metabolism in hypertriglyceridemic and normolipidemic patients with coronary heart disease
GL Vega, WF Beltz and SM Grundy
The turnover rates of low density lipoprotein-apolipoprotein B (LDL- apoB)
were determined in 32 men with coronary heart disease (CHD) and 11 control
men with normal plasma lipids. Thirty patients with CHD had normal levels
of LDL-cholesterol (LDL-C); of these patients, 9 had hypertriglyceridemia
and 21 had normal plasma lipids. Mean concentrations of total cholesterol
and LDL-C were similar among the control subjects and CHD patients,
although the latter had significantly lower HDL-C. In control subjects,
transport rates and fractional catabolic rates (FCR) of LDL-B were 10.6 +/-
0.5 (SEM) mg/kg- day and 0.31 +/- 0.01 pools/day, respectively. In 10
hypertriglyceridemic patients with CHD, transport rates were 21.7 +/- 1.7
mg/kg-day, and FCRs averaged 0.56 +/- 0.06 pools/day; both were
significantly higher than normal (P less than 0.05). Six normolipidemic
patients also had abnormally high transport rates of LDL-apoB (19.4 +/- 2.8
mg/kg-day) and FCRs (0.51 +/- 0.03 pools/day); again both were higher than
normal. The remaining 16 normolipidemic patients with CHD had normal
transport rates (9.9 +/- 0.6 mg/kg-day) and FCRs (0.28 +/- 0.01 pools/day).
Thus, hypertriglyceridemic patients with CHD and a portion of
normolipidemic patients with CHD were characterized by increases in both
transport and fractional catabolic rate of LDL-apoB; these abnormalities in
LDL metabolism may have contributed to their coronary heart disease.
However, the majority of normolipidemic patients with CHD did not show a
distinct defect in their LDL metabolism.
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