HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Aubourg, P. Articles by Rocchiccioli, F. Search for Related Content PubMed PubMed Citation Articles by Aubourg, P. Articles by Rocchiccioli, F. Social Bookmarking                      What's this?

Journal of Lipid Research, Vol 26, 263-267, Copyright © 1985 by Lipid Research, Inc.

ARTICLES

Capillary gas-liquid chromatographic-mass spectrometric measurement of very long chain (C22 to C26) fatty acids in microliter samples of plasma

P Aubourg, PF Bougneres and F Rocchiccioli

In order to quantify accurately the plasma content of very long chain fatty acids, we have developed a selected ion monitoring gas-liquid chromatographic-mass spectrometric micromethod which allows all of these acids (22:0, 24:1, 24:0, 26:1, and 26:0) to be determined simultaneously in the same 0.5-ml plasma sample; 17:0 and 27:0 fatty acids are used as assay internal standards. For plasma samples in the range equivalent to the various very long chain fatty acid physiological concentrations, assay precision was +/- 2%. The present method has been successfully applied to the biological recognition of patients with adrenoleukodystrophy, their heterozygote relatives, and of cerebro-hepato-renal syndrome and neonatal adrenoleukodystrophy.
CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this?

This article has been cited by other articles:

				P. Aubourg, C. Adamsbaum, M.-C. Lavallard-Rousseau, F. Rocchiccioli, N. Cartier, I. Jambaque, C. Jakobezak, A. Lemaitre, F. Boureau, C. Wolf, et al. A Two-Year Trial of Oleic and Erucic Acids ("Lorenzo's Oil") as Treatment for Adrenomyeloneuropathy N. Engl. J. Med., September 9, 1993; 329(11): 745 - 752. [Abstract] [Full Text]