HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Vetter, R. D. Articles by Patton, J. S. Search for Related Content PubMed PubMed Citation Articles by Vetter, R. D. Articles by Patton, J. S. Social Bookmarking                      What's this?

Journal of Lipid Research, Vol 26, 428-434, Copyright © 1985 by Lipid Research, Inc.

ARTICLES

Coassimilation of dietary fat and benzo(a)pyrene in the small intestine: an absorption model using the killifish

RD Vetter, MC Carey and JS Patton

Benzo(a)pyrene (BP) was dissolved in dietary fat and fed in a single dose to killifish (Fundulus heteroclitus). Fluorescence microscopic examinations of small intestinal content and frozen sections of whole small intestine revealed that during fat digestion BP was codispersed in liquid crystalline product phases produced during lipolysis (1979. Patton, J. S., and M. C. Carey, Science. 204: 145-148) and then coabsorbed with dietary lipid followed by its reappearance in intracellular fat droplets. During the time that the absorbed fat remained in the enterocytes, BP fluorescence was initially concentrated in the intracellular fat droplets and then spread throughout the cytosol of the enterocytes. Tissue analyses showed that BP was rapidly metabolized in the intestine and transported to the gallbladder. These studies show that separation of a dissolved hydrophobic carcinogen from dietary fat occurs primarily after the fat has been digested, dispersed, absorbed, and reassembled in the enterocyte. The inability of the enterocyte to discriminate between dietary fat and dissolved carcinogenic compounds may be a partial explanation of the observed link between high fat diets and the incidence of some cancers. In vertebrates, the intestine and not the liver, appears to be the major site of metabolism of dietary polycyclic aromatic hydrocarbons (PAHs).
CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this?

This article has been cited by other articles:

				J. W. Nichols, P. N. Fitzsimmons, and F. W. Whiteman A Physiologically Based Toxicokinetic Model for Dietary Uptake of Hydrophobic Organic Compounds by Fish: II. Simulation of Chronic Exposure Scenarios Toxicol. Sci., February 1, 2004; 77(2): 219 - 229. [Abstract] [Full Text] [PDF]

				J. W. Nichols, P. N. Fitzsimmons, F. W. Whiteman, D. W. Kuehl, B. C. Butterworth, and C. T. Jenson Dietary Uptake Kinetics of 2,2',5,5'-Tetrachlorobiphenyl in Rainbow Trout Drug Metab. Dispos., July 1, 2001; 29(7): 1013 - 1022. [Abstract] [Full Text] [PDF]

				A. M. Doi, Z. Lou, E. Holmes, C.-L. J. Li, C. S. Venugopal, M. O. James, and K. M. Kleinow Effect of Micelle Fatty Acid Composition and 3,4,3',4'-Tetrachlorobiphenyl (TCB) Exposure on Intestinal [14C]-TCB Bioavailability and Biotransformation in Channel Catfish in Situ Preparations Toxicol. Sci., May 1, 2000; 55(1): 85 - 96. [Abstract] [Full Text] [PDF]