HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Sundaram, K. S. Articles by Lev, M. Search for Related Content PubMed PubMed Citation Articles by Sundaram, K. S. Articles by Lev, M. Social Bookmarking                      What's this?

Journal of Lipid Research, Vol 26, 473-477, Copyright © 1985 by Lipid Research, Inc.

ARTICLES

Inhibition of cerebroside synthesis in the brains of mice treated with L-cycloserine

KS Sundaram and M Lev

Subcutaneous injection of L-cycloserine resulted in a 28% reduction in cerebroside levels in mouse brain but had no effect on the levels of gangliosides. In contrast, intraperitoneal injection results in a reduction of ganglioside as well as cerebroside + sulfatide levels. The route of injection influenced the degree of 3-ketodihydrosphingosine synthase inhibition. Intraperitoneal injection caused a rapid decrease in synthase activity followed by recovery over 48 hr, whereas subcutaneous injection resulted in no inhibition over this time; only after daily injection for a week was synthase activity reduced 35%. One week following cessation of L-cycloserine administration, enzyme activity had recovered, whereas the cerebroside level continued to fall. All lipids and enzymes showed normal levels 3 weeks post- cycloserine administration. L-[3H]serine incorporation into glycolipids showed that cerebroside synthesis was most affected, whereas sulfatide synthesis was less affected. One week after cessation of cycloserine treatment, cerebroside synthesis was still severely inhibited, whereas sulfatide levels were near normal. Two weeks after cessation of L- cycloserine administration, synthesis of these glycolipids was similar to that of controls.
CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this?

This article has been cited by other articles:

				D. A. Wenger, S. Coppola, and S.-L. Liu Insights Into the Diagnosis and Treatment of Lysosomal Storage Diseases Arch Neurol, March 1, 2003; 60(3): 322 - 328. [Abstract] [Full Text] [PDF]