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Journal of Lipid Research, Vol 26, 549-555, Copyright © 1985 by Lipid Research, Inc.
ST Kunitake, KJ La Sala and JP Kane
Among the apoA-I-containing lipoproteins isolated by selected-affinity
immunosorption from human serum and plasma, we have identified a
subpopulation which, unlike the bulk of high density lipoproteins, has
pre-beta electrophoretic mobility. This pre-beta subpopulation can be
observed directly in fresh plasma by immunoelectrophoresis. It contains
phospholipid and free and esterified cholesterol, but protein constitutes
90% of its mass. Apolipoprotein A-I is the predominant apolipoprotein in
this subpopulation; apolipoprotein A-II and the B lipoproteins are not
detected. The protein moiety of this subpopulation exhibits markedly lower
helicity than that of high density lipoproteins isolated by
ultracentrifugation.
ARTICLES
Apolipoprotein A-I-containing lipoproteins with pre-beta electrophoretic mobility
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