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Journal of Lipid Research, Vol 26, 566-574, Copyright © 1985 by Lipid Research, Inc.
JR Crouse, JS Parks, HM Schey and FR Kahl
Low density lipoprotein molecular weight (LDL MW) correlates positively
with coronary artery disease in cholesterol-fed nonhuman primates. To
evaluate this in human beings with coronary artery disease (CAD) we
measured LDL MW in 93 volunteers undergoing coronary angiography (47
controls and 46 CAD patients). LDL MW of CAD patients was less than that of
controls (patients, 2.79 +/- 0.17 g/mumol; controls, 2.93 +/- 0.19 g/mumol;
P less than 0.001). However, LDL MW decreased as plasma triglyceride
increased and concentrations of triglyceride were greater in CAD patients
than in controls. Since decreased LDL MW is likely to result, in part, from
increased plasma triglyceride concentrations, we attempted to determine the
effect of triglyceride on the relation of LDL MW to CAD in this study.
After covariance adjustment for triglyceride, there was no LDL MW
difference between CAD patients and controls. Because LDL heterogeneity has
been identified in other studies and was apparent on inspection of agarose
column profiles of LDL of these volunteers, we sought differences in the
profiles that might distinguish coronary disease cases from controls. No
differences could be found. In addition, we used density gradient
ultracentrifugation to characterize LDL in more detail in a subset of
volunteers who had a wide range of plasma triglyceride concentrations (50
mg/dl to 900 mg/dl). LDL mean hydrated density was inversely related to LDL
MW and increased as triglyceride increased. The increase in peak density
was reflected in an increase in percent of total protein in LDL found to
have d greater than 1.045 g/ml and a decrease in protein in LDL of d
1.035-1.040 g/ml. These interrelationships were not apparently influenced
by coronary artery status.
ARTICLES
Studies of low density lipoprotein molecular weight in human beings with coronary artery disease
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M.C. Carr, A.F. Ayyobi, S.J. Murdoch, S.S. Deeb, and J.D. Brunzell Contribution of Hepatic Lipase, Lipoprotein Lipase, and Cholesteryl Ester Transfer Protein to LDL and HDL Heterogeneity in Healthy Women Arterioscler. Thromb. Vasc. Biol., April 1, 2002; 22(4): 667 - 673. [Abstract] [Full Text] [PDF]
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