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Journal of Lipid Research, Vol 26, 950-954, Copyright © 1985 by Lipid Research, Inc.

ARTICLES

Cholesterol metabolism: use of D2O for determination of synthesis rate in cell culture

AL Esterman, BI Cohen and NB Javitt

Cholesterol synthesis in cell culture in the presence of D2O yields a spectrum of enriched molecules having a relative abundance that indicates random substitution of deuterium for hydrogen. Quantitation of the absolute rate of cholesterol synthesis is obtained by isotope ratio mass spectrometry. Mevinolin and 26-hydroxycholesterol both decrease cholesterol synthesis rate but have a discordant effect on HMG- CoA reductase activity.
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