Journal of Lipid Research, Vol 26, 1112-1119, Copyright © 1985 by Lipid Research, Inc.
Retinol and retinyl esters in parenchymal and nonparenchymal rat liver cell fractions after long-term administration of ethanol
M Rasmussen, R Blomhoff, P Helgerud, LA Solberg, T Berg and KR Norum
Chronic ethanol consumption reduces the liver retinoid store in man and
rat. We have studied the effect of ethanol on some aspects of retinoid
metabolism in parenchymal and nonparenchymal liver cells. Rats fed 36% of
total energy intake as ethanol for 5-6 weeks had the liver retinoid
concentration reduced to about one-third, as compared to pair-fed controls.
The reduction in liver retinoid affected both the parenchymal and the
nonparenchymal cell fractions. Plasma retinol level was normal. Liver
uptake of injected chylomicron [3H]retinyl ester was similar in the
experimental and control group. The transport of retinoid from the
parenchymal to the nonparenchymal cells was not found to be significantly
retarded in the ethanol-fed rats. Despite the reduction in total retinoid
level in liver, the concentrations of unesterified retinol and retinyl
oleate were increased in the ethanol fed rats. Hepatic retinol
esterification was not significantly affected in the ethanol-fed rats.
Since our study has demonstrated that liver uptake of chylomicron retinyl
ester is not impaired in the ethanol-fed rat, we suggest that liver
retinoid metabolism may be increased.
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