HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Kushwaha, R. S. Articles by McGill, H. C. Search for Related Content PubMed PubMed Citation Articles by Kushwaha, R. S. Articles by McGill, H. C., Jr Social Bookmarking                      What's this?

Journal of Lipid Research, Vol 27, 497-507, Copyright © 1986 by Lipid Research, Inc.

ARTICLES

Metabolism of apoprotein B in selectively bred baboons with low and high levels of low density lipoproteins

RS Kushwaha, GM Barnwell, KD Carey and HC McGill Jr

Very low density lipoprotein (VLDL) and low density lipoprotein (LDL) apoprotein (apo)-B turnover rates were measured simultaneously by injecting 131I-labeled VLDL and 125I-labeled LDL into fasting baboons (Papio sp.) selectively bred for high serum cholesterol levels and having either low or high LDL levels. The radioactivities in VLDL, intermediate density lipoprotein (IDL), LDL apoB, and urine were measured at intervals between 5 min and 6 days. Kinetic parameters for apoB were calculated in each baboon fed a chow diet or a high cholesterol, high fat diet (HCHF). VLDL apoB residence times were similar in the two groups of animals fed chow; they were increased by HCHF feeding in high LDL animals, but not in low LDL animals. Production rates of VLDL apoB were decreased by the HCHF diet in both high and low LDL animals. Most of the radioactivity from VLDL apoB was transferred to IDL. However, a greater proportion of radioactivity was removed directly from IDL apoB in low LDL animals than in high LDL animals, and only about one-third appeared in LDL. In high LDL animals, a greater proportion of this radioactivity was converted to LDL (61.4 +/- 7.2% in chow-fed animals and 49.2 +/- 10.9% in animals fed the HCHF diet; mean +/- SEM, n = 5). Production rates for LDL apoB were higher in high LDL animals than those in low LDL animals on both diets. The HCHF diet increased residence times of LDL apoB without changing production rates in both groups. VLDL apoB production was not sufficient to account for LDL apoB production in high LDL animals, a finding that suggested that a large amount of LDL apoB was derived from a source other than VLDL apoB in these animals.
CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this?

This article has been cited by other articles:

				D. L. Rainwater, C. M. Kammerer, J. E. Hixson, K. D. Carey, K. S. Rice, B. Dyke, J. F. VandeBerg, S. H. Slifer, L. D. Atwood, H. C. McGill Jr, et al. Two Major Loci Control Variation in ß-Lipoprotein Cholesterol and Response to Dietary Fat and Cholesterol in Baboons Arterioscler. Thromb. Vasc. Biol., July 1, 1998; 18(7): 1061 - 1068. [Abstract] [Full Text] [PDF]