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Journal of Lipid Research, Vol 27, 875-883, Copyright © 1986 by Lipid Research, Inc.
SK Erickson and PE Fielding
The human hepatoma cell line Hep-G2 has been shown to express the major
enzymes of intra- and extracellular cholesterol metabolism. These include
lecithin:cholesterol acyltransferase, acyl coenzyme A:cholesterol
acyltransferase, 3-hydroxy-3-methylglutaryl coenzyme A reductase, and
cholesterol-7 alpha-hydroxylase. Regulatory mechanisms that have been
described in other hepatic systems also appear to be active in Hep-G2
cells: perturbations of cholesterol and triglyceride metabolism affected
the enzyme activities and the accumulation of specific apolipoproteins in
the culture media. The results indicate that studies of Hep-G2 cells may
provide useful information for the elucidation of mechanisms of regulation
of human hepatocyte cholesterol, lipoprotein, and biliary metabolism.
ARTICLES
Parameters of cholesterol metabolism in the human hepatoma cell line, Hep-G2
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