Journal of Lipid Research, Vol 27, 925-929, Copyright © 1986 by Lipid Research, Inc.
Neutral glyceride synthesis from glucose in human adipose tissue: comparison between growing and mature subjects
A Taniguchi, T Kono, H Okuda, F Oseko, I Nagata, K Kataoka and H Imura
Basal and insulin-stimulated neutral glyceride syntheses from glucose were
studied in fat cells of different size (fat cell volume, 0.07- 0.20,
0.20-0.60, 0.60-1.00, 1.00-1.50 micron3 X 10(6)) obtained from subcutaneous
adipose tissues in 20 subjects aged 3 months to 67 years. In 0.07-0.20 or
0.20-0.60 micron3 X 10(6) fat cells, the basal rate of glucose conversion
to neutral glyceride was significantly lower in mature (36 to 67 years old)
than in growing (0 to 12 years old) subjects. In 0.60-1.00 or 1.00-1.50
micron3 X 10(6) fat cells, however, basal rate was not significantly
different between the two groups. The stimulating effect of insulin on
conversion of glucose to neutral glyceride was not significantly different
from the basal rate in fat cells of each size taken from the mature
subjects, whereas in fat cells from growing subjects, it was significantly
different from the basal rate in each fat cell size category. These results
indicate that when fat cell size is taken into account, not only is the
rate of basal glucose conversion to neutral glyceride higher in growing
subjects but also its responsiveness to exogenous insulin, and that insulin
insensitivity of large fat cells, reported previously, may be influenced by
age.
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