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Journal of Lipid Research, Vol 28, 1137-1143, Copyright © 1987 by Lipid Research, Inc.
I Bjorkhem, T Miettinen, E Reihner, S Ewerth, B Angelin and K Einarsson
The possibility that the serum concentrations of various cholesterol
precursors may reflect the activity of the hepatic HMG-CoA reductase was
investigated in humans under different conditions. The serum levels of
squalene, free and esterified lanosterol, (4 alpha, 4 beta, 14 alpha-
trimethyl-5 alpha-cholest-8, 24-dien-3 beta-ol), two dimethylsterols (4
alpha, 4 beta-dimethyl-5 beta-cholest-8-en-3 beta-ol and 4 alpha, 4
beta-dimethyl-5 alpha-cholest-8, 24-dien-3 beta-ol), two methostenols (4
alpha-methyl-5 alpha-cholest-7-en-3 beta-ol and 4 alpha-methyl-5
alpha-cholest-8-en-3 beta-ol), two lathosterols (5 alpha-cholest-7-en-3
beta-ol and 5 alpha-cholest-8-en-3 beta-ol) and desmosterol (cholest-5,
24-dien-3 beta-ol) were measured in untreated patients (n = 7) and patients
treated with cholestyramine (QuestranR, 8 g twice daily for 2- 3 weeks, n =
5) or chenodeoxycholic acid (15 mg/kg body weight daily for 3-4 weeks, n =
8) prior to elective cholecystectomy. The activity of the hepatic
microsomal HMG-CoA reductase was measured in liver biopsies taken in
connection with the operation.(ABSTRACT TRUNCATED AT 250 WORDS)
ARTICLES
Correlation between serum levels of some cholesterol precursors and activity of HMG-CoA reductase in human liver
Department of Clinical Chemistry, Karolinska Institutet, Huddinge University Hospital, Stockholm, Sweden.
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