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Journal of Lipid Research, Vol 28, 144-151, Copyright © 1987 by Lipid Research, Inc.
N Yamamoto, M Saitoh, A Moriuchi, M Nomura and H Okuyama
Spontaneously hypertensive rats (SHR) and normotensive control,
Wistar/Kyoto (WKY) rats through two generations were fed a semipurified
diet supplemented either with safflower oil (rich in linoleate) or with
perilla oil (rich in alpha-linolenate). The cerebral lipid contents and
phospholipid compositions did not differ between the two dietary groups of
SHR rats. There were also no differences in the unsaturated/saturated
ratios of individual phospholipids or the proportions of plasma-logens.
However, the proportions of (n-3) and (n- 6) fatty acids were significantly
different. Decreases in the proportions of docosahexaenoate [22:6 (n-3)] in
phosphatidylethanolamine and phosphatidylserine in the safflower oil group
were compensated for with increases in the proportions of docosatetraenoic
[22:4 (n-6)] and docosapentaenoic [22:5 (n-6)] acids as compared with the
perilla oil group. These differences in phospholipid acyl chains were much
smaller than the difference in the proportions of linoleate and
alpha-linolenate of the diets. In a brightness-discrimination learning
test, the total number of responses to the positive and negative stimuli
were less in the groups fed perilla oil. However, the
alpha-linolenate-deficient group took longer to decrease the frequency of
R- responses and therefore longer to learn the discrimination.
Consequently, the correct response ratios were higher in the perilla oil
groups than in the safflower oil groups. Thus, the dietary
alpha-linolenate/linoleate balance influenced the (n- 3)/(n-6) balance of
polyenoic fatty acids differently among brain phospholipids.(ABSTRACT
TRUNCATED AT 250 WORDS)
ARTICLES
Effect of dietary alpha-linolenate/linoleate balance on brain lipid compositions and learning ability of rats
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