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Journal of Lipid Research, Vol 29, 287-292, Copyright © 1988 by Lipid Research, Inc.

ARTICLES

Sterol carrier protein2-like activity in rat intestine

A Kharroubi, JA Wadsworth, R Chanderbhan, P Wiesenfeld, B Noland, T Scallen, GV Vahouny and LL Gallo
Department of Biochemistry, George Washington University School of Medicine and Health Sciences, Washington, DC 20037.

A sterol carrier protein2 (SCP2)-like activity has been demonstrated in rat intestinal mucosal homogenates and in isolated intestinal cells from both crypt and villus zones. The results indicate the presence of a protein with similar molecular weight and antigenicity to that of authentic SCP2 purified from rat liver cytosol. Like liver SCP2, mucosal cytosol stimulates pregnenolone production in rat adrenal mitochondria and acyl coenzyme A:cholesterol acyltransferase activity of liver and mucosal microsomes. The distribution of SCP2-like activity as determined by radioimmunoassay indicates high levels in mitochondria and cytosol and relatively lower levels in microsomes and in brush- border membranes. The widespread distribution of SCP2-like protein in the intestine is consistent with potential transfer functions in all phases of cholesterol processing.
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