Journal of Lipid Research, Vol 29, 293-298, Copyright © 1988 by Lipid Research, Inc.
Role of apolipoproteins E and C in type V hyperlipoproteinemia
T Kuusi, MR Taskinen, T Solakivi and R Kauppinen-Makelin
Second Department Medicine, University of Helsinki, Finland.
Type V hyperlipoproteinemia is characterized by elevations of chylomicron
(CM) and very low density lipoprotein (VLDL) triglycerides. The development
of this lipid disorder involves a multitude of metabolic derangements
including deficient clearance of triglycerides and/or their increased
output aggravated by obesity, diabetes, alcohol intake, or use of some
hormones. Some studies have suggested that the apolipoprotein E4 phenotype
is involved in this dyslipoproteinemia but this concept is still a matter
of controversy. Therefore, we determined the apoE phenotype in 21 patients
with severe hypertriglyceridemia classified as type V. Their apoE4 gene
frequency was 0.595 which is 2.6- fold higher (P less than 0.001) than that
in the Finnish population. Correspondingly, their apoE3 gene frequency was
lower than that in the normal population. No differences were noted in
plasma lipoproteins of the apoE4 phenotypes and the other type V subjects.
The apolipoprotein C-II and C-III distribution was similar to that in
normolipidemic subjects. The results suggest that apoE4 may be involved in
the development of type V hyperlipoproteinemia.
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