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Journal of Lipid Research, Vol 29, 431-441, Copyright © 1988 by Lipid Research, Inc.
Hypolipidemic effect of beta, beta'-methyl-substituted hexadecanedioic acid (MEDICA 16) in normal and nephrotic rats
J Bar-Tana, G Rose-Kahn, B Frenkel, Z Shafer and M Fainaru
Department of Biochemistry, Jerusalem, Israel.
Treatment of normal or puromycin aminonucleoside-nephrotic rats, kept on a
balanced Purina chow diet, with beta, beta'-tetramethyl- substituted
hexadecanedioic acid (MEDICA 16) (Bar-Tana, J., G. Rose- Kahn, and M.
Srebnik. 1985. J. Biol. Chem. 260: 8404-8410) resulted in an acute
reversible inhibition of liver lipogenesis and cholesterogenesis with a
concomitant hypolipidemic effect which was sustained as long as the drug
was administered. The hypolipidemic effect in normal and nephrotic rats
consisted of 70-80% and 40-60% reduction in plasma VLDL-triacylglycerols
and cholesterol, respectively, with a respective increase in the
HDL-cholesterol/(VLDL + LDL)-cholesterol ratio. The observed hypolipidemic
effect was accompanied by a 10-fold decrease in VLDL-apoC-III content with
a concomitant enrichment of the VLDL fraction by VLDL remnants having an
increased apoB-100/apoB-48 ratio. The pharmacological reduction of VLDL by
MEDICA 16 may offer a treatment mode of choice for selected hyperlipidemic
states.

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Copyright © 1988 by the American Society for Biochemistry and Molecular Biology.
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