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Journal of Lipid Research, Vol 29, 469-479, Copyright © 1988 by Lipid Research, Inc.
JS Cohn, JR McNamara, SD Cohn, JM Ordovas and EJ Schaefer
Plasma lipoprotein changes were monitored for 12 hr after a fat-rich meal
(1 g of fat/kg body weight) in 22 subjects (9 males, 13 females, 22-79 yr
old). Plasma triglyceride, measured hourly, peaked once in some subjects,
but twice or three times in others. The magnitude of postprandial
triglyceridemia varied considerably between subjects (range: 650-4082
mg.hr/dl). Males tended to have greater postprandial triglyceridemia than
females, and elderly subjects had significantly (P less than 0.05) greater
postprandial triglyceridemia than younger subjects. Total plasma
cholesterol, measured every three hr, increased significantly (6.0 +/-
2.1%) in 7 subjects, decreased significantly (7.1 +/- 1.2%) in 10 subjects,
and remained unchanged in the remainder. Single spin ultracentrifugation
and dextran sulfate precipitation procedures were used to quantitate
triglyceride and cholesterol in triglyceride-rich lipoproteins (TRL, d less
than 1.006 g/ml), low density lipoproteins (LDL), and high density
lipoproteins (HDL). Plasma TRL and HDL triglyceride increased after the fat
meal, while LDL triglyceride decreased at 3 hr but increased at 9 and 12
hr. TRL cholesterol increased postprandially, while LDL and HDL cholesterol
decreased. Phospholipid (PL), free (FC) and esterified (EC) cholesterol
measurements were carried out on the plasma and lipoprotein fractions of 8
subjects. Plasma PL increased significantly at 3, 6, and 9 hr after the
fat-rich meal, due to increases in TRL and HDL PL. TRL CE increased
postprandially, but a greater decrease in LDL and HDL CE caused plasma CE
to be decreased. Plasma FC increased, predominantly due to an increase in
TRL FC. Plasma concentrations of apolipoprotein A- I and apolipoprotein B
both decreased after the fat-rich meal. The magnitude of postprandial
triglyceridemia was inversely correlated with HDL cholesterol levels (r =
-0.502, P less than 0.05) and positively correlated with age (r = -0.449, P
less than 0.05), fasting levels of plasma triglyceride (r = 0.636, P less
than 0.01), plasma apoB (r = 0.510, P less than 0.05), TRL triglyceride (r
= 0.564, P less than 0.01), TRL cholesterol (r = 0.480, P less than 0.05)
and LDL triglyceride (r = 0.566, P less than 0.01). Change in postprandial
cholesterolemia was inversely correlated with fasting levels of HDL
cholesterol (r = -0.451, P less than 0.05) and plasma apoA-I (r = - 0.436,
P less than 0.05).(ABSTRACT TRUNCATED AT 400 WORDS)
ARTICLES
Postprandial plasma lipoprotein changes in human subjects of different ages
USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111.
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