HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Cornwell, D. G. Articles by Robinson, H. B. Search for Related Content PubMed Articles by Cornwell, D. G. Articles by Robinson, H. B. Social Bookmarking                      What's this?

Journal of Lipid Research, Vol. 3, 65-70, January 1962
Copyright © 1962 by Lipid Research, Inc.

Studies on the absorption of beta-carotene and the distribution of total carotenoid in human serum lipoproteins after oral administration

David G. Cornwell , Fred A. Kruger , and Haynes B. Robinson

Department of Physiological Chemistry and Division of Endocrinology, Department of Medicine, Ohio State University, Columbus 10, Ohio

The carotenoid increment in human serum was measured after the oral administration of aqueous dispersions and lipid dispersions of ßbeta;-carotene with different test meal regimens. ßbeta;-caritebe was readukt absorbed in both forms. Absorption of the aqueous dispersion was similar when administered with either high lipid or protein-carbohydrate test meals. Aqueous dispersions were poorly absorbed by fasting subjects. The lipoprotein distribution of the serum carotenoid increment was determined in normal, hypercholesterolemic, and hyperlipemic subjects to investigate the absorption and transport pattern for ßbeta;-carotene. Peak carotenoid increments occurred first in the chylomicron and S_f 10-400 lipoprotein fractions, and considerably later in the S_f 0-10 fraction. A major part of the serum carotenoid increment was found in the S_f 0-10 lipoprotein fraction. This is reflected in the delayed peak found in serum carotenoid tolerance curves. Very little newly absorbed carotenoid was found in the high density lipoprotein fraction. Carotenoid-to-cholesterol and carotenoid-to-fatty acid ester ratios were determined after carotenoid administration and after a lipid test meal containing no carotenoid. These ratios indicated that the peak carotenoid increments represented newly absorbed carotenoid associated with specific lipoprotein fractions rather than rapid carotenoid exchange between lipoprotein fractions that varied in their total concentration. The absorption and transport of carotenoid was compared with the absorption and transport of other lipids. Portal absorption of at least a part of the ingested carotenoid is proposed as a possible explanation for the observed carotenoid transport pattern.

CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this?

This article has been cited by other articles:

				A. J Edwards, C.-S. You, J. E Swanson, and R. S Parker A novel extrinsic reference method for assessing the vitamin A value of plant foods Am. J. Clinical Nutrition, September 1, 2001; 74(3): 348 - 355. [Abstract] [Full Text]

				O. Sommerburg, J. E E Keunen, A. C Bird, and F. J G M van Kuijk Fruits and vegetables that are sources for lutein and zeaxanthin: the macular pigment in human eyes Br. J. Ophthalmol., August 1, 1998; 82(8): 907 - 910. [Abstract] [Full Text]