Journal of Lipid Research, Vol. 3, 88-91, January 1962
Copyright © 1962 by Lipid Research, Inc.
Hypocholesterolemic effect of methyltestosterone in rats
Liese L. Abell and Erwin H. Mosbach
Columbia University Research Service, Goldwater Memorial Hospital, Welfare Island, New York 17, N.Y., and Departments of Biochemistry and Medicine, College of Physicians and Surgeons, Columbia University
In rats fed a stock diet, the oral administration of 17 
-methyltestosterone (0.05% of the diet) produced a 46% average reduction of serum total cholesterol concentration. The ratio between the cholesterol content of the - and ßbeta;-lipoprotein fractions remained unchanged. In rats made mildly hypercholesterolemic by the addition of 1% cholesterol to the stock diet, the oral administration of 0.1% methyltestosterone prevented the rise in serum cholesterol concentration. This effect resulted primarily from a reduction of the cholesterol content of the -lipoprotein fraction. The production of a more intense hypercholesterolemia by the administration of 1% cholesterol plus 0.5% cholic acid abolished the hypocholesterolemic action of 0.1% methyltestosterone. Analyses of the cholesterol content of the liver and intestinal wall indicated, in animals on both low and high cholesterol diets, that methyltestosterone did not exert its effect by producing a redistribution of the cholesterol between the serum and the tissues examined.
Submitted on May 23, 1961
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