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Journal of Lipid Research, Vol. 3, 177-180, April 1962
Copyright © 1962 by Lipid Research, Inc.

The incorporation of P³² into the inositol phosphatides of rat brain

H. Wagner , Ä. Lissau , J. Hölzl , and L. Hörhammer

Institut für Pharmazeutische Arzneimittellehre der Universität München, München, Germany

The inositol phosphatide fraction of rat brain has been separated by chromatography on formaldehyde-treated paper into monophosphoinositide and two other inositol-containing phosphatides named phosphoinositide 1 and 2. Quantitative determination of the ether-soluble phosphatides gave the following values for rat brains of 450 to 500 mg dry weight: 14 to 21 mg phosphatidylcholine and phosphatidylethanolamine, 3.5 to 4.6 mg phosphatidylserine, 0.9 to 1.3 mg monophosphoinositide, and 0.1 to 0.2 mg each of phosphoinositide 1 and 2. All three inositol phosphatides incorporated P³² at a significantly higher rate than the other brain phosphatides. Of the three, monophosphoinositide always had the lowest specific activity; after 16 and 32 hours, phosphoinositide 2, which is probably identical with the triphosphoinositide of Ballou, had the highest specific activity.

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