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Journal of Lipid Research, Vol. 3, 238-242, April 1962
Copyright © 1962 by Lipid Research, Inc.

Metabolism of methyl elaidate

G. A. Dhopeshwarkar and James F. Mead

Department of Physiological Chemistry, School of Medicine, University of California, Los Angeles, California

Methyl elaidate-1-C¹⁴ was fed to fat-deficient guinea pigs. Very little incorporation of the radioactivity was found in the glycerides or phospholipids under these conditions. Methyl ester seemed to have been absorbed without complete hydrolysis and deposited in body tissues as the methyl ester. Intestinal lipids from these animals showed the presence of unhydrolyzed free methyl esters even after a period of 4 hours. Percentage distribution of the radioactivity in the stearic acid isolated from these animals shows direct in vivo hydrogenation of elaidic acid to stearic acid.

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