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Journal of Lipid Research, Vol. 3, 333-338, July 1962
Copyright © 1962 by Lipid Research, Inc.

The uptake and metabolism of C¹⁴-labeled fatty acids by macrophages in vitro

A. J. Day and N. H. Fidge

Department of Human Physiology and Pharmacology, University of Adelaide, South Australia

Macrophages obtained from the peritoneal cavity of rabbits were incubated in vitro in the presence of C¹⁴-labeled sodium palmitate, and the uptake of fatty acid and its subsequent incorporation into other lipid fractions was determined. Up to 21% of the C¹⁴-labeled sodium palmitate added to the incubation medium was taken up by the macrophages. Most of this was converted to triglyceride and phospholipid, but a small amount was converted to cholesterol ester and to mono- and diglyceride.

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