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Journal of Lipid Research, Vol. 3, 397-404, October 1962
Copyright © 1962 by Lipid Research, Inc.

Turnover of deoxycholic acid in the rabbit

K. Hellström and J. Sjövall

Department of Medicine, Serafimerlasarettet, and Department of Chemistry, Karolinska Institutet, Stockholm, Sweden

A method for studying the turnover of deoxycholic acid in the rabbit is described. The mean values for half-life, pool size, and daily production of deoxycholic acid were 6.8 days, 700 mg, and 73.4 mg, respectively, in 26 rabbits on a diet of conventional commercial food pellets. Of the bile acid pool, 97-98% was present in liver, gallbladder, and gastro-intestinal tract. A comparatively large amount (10%) was present in the stomach. Fecal excretion was the main excretory pathway for bile acids. An amount corresponding to 10% of the daily synthesis of deoxycholic acid was excreted in the urine. The concentration of bile acids in blood was calculated to be 0.26-3.10 mg/100 ml of whole blood.

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