| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Journal of Lipid Research, Vol 30, 423-431, Copyright © 1989 by Lipid Research, Inc.
ARTICLES |
CF Semenkovich, SH Chen, M Wims, CC Luo, WH Li and L Chan
Department of Medicine, Baylor College of Medicine, Houston, TX 77030.
Lipoprotein lipase (LPL) and hepatic lipase (HL) enzyme activities were previously reported to be regulated during development, but the underlying molecular events are unknown. In addition, little is known about LPL evolution. We cloned and sequenced a complete mouse LPL cDNA. Comparison of sequences from mouse, human, bovine, and guinea pig cDNAs indicated that the rates of evolution of mouse, human, and bovine LPL are quite low, but guinea pig LPL has evolved several times faster than the others. 32P-Labeled mouse LPL and rat HL cDNAs were used to study lipase mRNA tissue distribution and developmental regulation in the rat. Northern gel analysis revealed the presence of a single 1.87 kb HL mRNA species in liver, but not in other tissues including adrenal and ovary. A single 4.0 kb LPL mRNA species was detected in epididymal fat, heart, psoas muscle, lactating mammary gland, adrenal, lung, and ovary, but not in adult kidney, liver, intestine, or brain. Quantitative slot- blot hybridization analysis demonstrated the following relative amounts of LPL mRNA in rat tissues: adipose, 100%; heart, 94%; adrenal, 6.6%; muscle, 3.8%; lung, 3.0%; kidney, 0%; adult liver, 0%. The same quantitative analysis was used to study lipase mRNA levels during development. There was little postnatal variation in LPL mRNA in adipose tissue; maximal levels were detected at the earliest time points studied for both inguinal and epididymal fat. In heart, however, LPL mRNA was detected at low levels 6 days before birth and increased 278-fold as the animals grew to adulthood.(ABSTRACT TRUNCATED AT 250 WORDS)
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati What's this?
This article has been cited by other articles:
|
|
 |
|
  S. Luci, B. Giemsa, H. Kluge, and K. Eder Clofibrate causes an upregulation of PPAR-{alpha} target genes but does not alter expression of SREBP target genes in liver and adipose tissue of pigs Am J Physiol Regulatory Integrative Comp Physiol, July 1, 2007; 293(1): R70 - R77. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. L. Dichek, N. Agrawal, N. E. Andaloussi, and K. Qian Attenuated corticosterone response to chronic ACTH stimulation in hepatic lipase-deficient mice: evidence for a role for hepatic lipase in adrenal physiology Am J Physiol Endocrinol Metab, May 1, 2006; 290(5): E908 - E915. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Rip, M. C. Nierman, N. J. Wareham, R. Luben, S. A. Bingham, N. E. Day, J. N.I. van Miert, B. A. Hutten, J. J.P. Kastelein, J. A. Kuivenhoven, et al. Serum Lipoprotein Lipase Concentration and Risk for Future Coronary Artery Disease: The EPIC-Norfolk Prospective Population Study Arterioscler. Thromb. Vasc. Biol., March 1, 2006; 26(3): 637 - 642. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. K. Vikramadithyan, K. Hirata, H. Yagyu, Y. Hu, A. Augustus, S. Homma, and I. J. Goldberg Peroxisome Proliferator-Activated Receptor Agonists Modulate Heart Function in Transgenic Mice with Lipotoxic Cardiomyopathy J. Pharmacol. Exp. Ther., May 1, 2005; 313(2): 586 - 593. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. L. S. Lindegaard, J. E. Nielsen, J. Hannibal, and L. B. Nielsen Expression of the endothelial lipase gene in murine embryos and reproductive organs J. Lipid Res., March 1, 2005; 46(3): 439 - 444. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. Niho, M. Mutoh, M. Takahashi, K. Tsutsumi, T. Sugimura, and K. Wakabayashi Concurrent suppression of hyperlipidemia and intestinal polyp formation by NO-1886, increasing lipoprotein lipase activity in Min mice PNAS, February 22, 2005; 102(8): 2970 - 2974. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Ruge, L. Neuger, V. Sukonina, G. Wu, S. Barath, J. Gupta, B. Frankel, B. Christophersen, K. Nordstoga, T. Olivecrona, et al. Lipoprotein lipase in the kidney: activity varies widely among animal species Am J Physiol Renal Physiol, December 1, 2004; 287(6): F1131 - F1139. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. T. Waylan, J. D. Dunn, B. J. Johnson, J. P. Kayser, and E. K. Sissom Effect of flax supplementation and growth promotants on lipoprotein lipase and glycogenin messenger RNA concentrations in finishing cattle J Anim Sci, June 1, 2004; 82(6): 1868 - 1875. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 I. V. Fuki, N. Blanchard, W. Jin, D. H. L. Marchadier, J. S. Millar, J. M. Glick, and D. J. Rader Endogenously Produced Endothelial Lipase Enhances Binding and Cellular Processing of Plasma Lipoproteins via Heparan Sulfate Proteoglycan-mediated Pathway J. Biol. Chem., September 5, 2003; 278(36): 34331 - 34338. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Merkel, J. Heeren, W. Dudeck, F. Rinninger, H. Radner, J. L. Breslow, I. J. Goldberg, R. Zechner, and H. Greten Inactive Lipoprotein Lipase (LPL) Alone Increases Selective Cholesterol Ester Uptake in Vivo, Whereas in the Presence of Active LPL It Also Increases Triglyceride Hydrolysis and Whole Particle Lipoprotein Uptake J. Biol. Chem., February 22, 2002; 277(9): 7405 - 7411. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Zhang, J. J. Repa, K. Gauthier, and D. J. Mangelsdorf Regulation of Lipoprotein Lipase by the Oxysterol Receptors, LXRalpha and LXRbeta J. Biol. Chem., November 9, 2001; 276(46): 43018 - 43024. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. Hennig, M. Toborek, and C. J. McClain High-Energy Diets, Fatty Acids and Endothelial Cell Function: Implications for Atherosclerosis J. Am. Coll. Nutr., April 1, 2001; 20(2): 97 - 105. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Van Eck, R. Zimmermann, P. H. E. Groot, R. Zechner, and T. J. C. Van Berkel Role of Macrophage-Derived Lipoprotein Lipase in Lipoprotein Metabolism and Atherosclerosis Arterioscler. Thromb. Vasc. Biol., September 1, 2000; 20 (9): e53 - e62. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. L. Hildebrandt and P. D. Neufer Exercise attenuates the fasting-induced transcriptional activation of metabolic genes in skeletal muscle Am J Physiol Endocrinol Metab, June 1, 2000; 278(6): E1078 - E1086. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Chapman, L. M. Morgan, and M. C. Murphy Maternal and Early Dietary Fatty Acid Intake: Changes in Lipid Metabolism and Liver Enzymes in Adult Rats J. Nutr., January 1, 2000; 130(2): 146 - 151. [Abstract] [Full Text]
|
|
|
|
|
|
B. A. Marshall, K. Tordjman, H. H. Host, N. J. Ensor, G. Kwon, C. A. Marshall, T. Coleman, M. L. McDaniel, and C. F. Semenkovich Relative Hypoglycemia and Hyperinsulinemia in Mice with Heterozygous Lipoprotein Lipase (LPL) Deficiency. ISLET LPL REGULATES INSULIN SECRETION J. Biol. Chem., September 24, 1999; 274(39): 27426 - 27432. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Li, J. O. Holloszy, and C. F. Semenkovich Respiratory Uncoupling Induces delta -Aminolevulinate Synthase Expression through a Nuclear Respiratory Factor-1-dependent Mechanism in HeLa Cells J. Biol. Chem., June 18, 1999; 274(25): 17534 - 17540. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Levak-Frank, W. Hofmann, P. H. Weinstock, H. Radner, W. Sattler, J. L. Breslow, and R. Zechner Induced mutant mouse lines that express lipoprotein lipase in cardiac muscle, but not in skeletal muscle and adipose tissue, have normal plasma triglyceride and high-density lipoprotein-cholesterol levels PNAS, March 16, 1999; 96(6): 3165 - 3170. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Chen, S. Jackson, M. Doro, and S. McGowan Perinatal expression of genes that may participate in lipid metabolism by lipid-laden lung fibroblasts J. Lipid Res., December 1, 1998; 39(12): 2483 - 2492. [Abstract] [Full Text]
|
|
|
|
|
|
D. A. Towler, M. Bidder, T. Latifi, T. Coleman, and C. F. Semenkovich Diet-induced Diabetes Activates an Osteogenic Gene Regulatory Program in the Aortas of Low Density Lipoprotein Receptor-deficient Mice J. Biol. Chem., November 13, 1998; 273(46): 30427 - 30434. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. F. Semenkovich, T. Coleman, and A. Daugherty Effects of heterozygous lipoprotein lipase deficiency on diet-induced atherosclerosis in mice J. Lipid Res., June 1, 1998; 39(6): 1141 - 1151. [Abstract] [Full Text]
|
|
|
|
|
|
S. Salinelli, J.-Y. Lo, M. P. Mims, E. Zsigmond, L. C. Smith, and L. Chan Structure-Function Relationship of Lipoprotein Lipase-mediated Enhancement of Very Low Density Lipoprotein Binding and Catabolism by the Low Density Lipoprotein Receptor. FUNCTIONAL IMPORTANCE OF A PROPERLY FOLDED SURFACE LOOP COVERING THE CATALYTIC CENTER J. Biol. Chem., September 6, 1996; 271(36): 21906 - 21913. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Staels, G. Martin, M. Martinez, C. Albert, J. Peinado-Onsurbe, R. Saladin, D. W. Hum, M. Reina, S. Vilaro, and J. Auwerx Expression and Regulation of the Lipoprotein Lipase Gene in Human Adrenal Cortex J. Biol. Chem., July 19, 1996; 271(29): 17425 - 17432. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. A. Dugi, H.én L. Dichek, and S. Santamarina-Fojo Human Hepatic and Lipoprotein Lipase: The Loop Covering the Catalytic Site Mediates Lipase Substrate Specificity J. Biol. Chem., October 27, 1995; 270(43): 25396 - 25401. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Umans, L. Serneels, L. Overbergh, K. Lorent, F. Van Leuven, and H. Van den Berghe Targeted Inactivation of the Mouse alpha(2)-Macroglobulin Gene J. Biol. Chem., August 25, 1995; 270(34): 19778 - 19785. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Coleman, R. L. Seip, J. M. Gimble, D. Lee, N. Maeda, and C. F. Semenkovich COOH-terminal Disruption of Lipoprotein Lipase in Mice Is Lethal in Homozygotes, but Heterozygotes Have Elevated Triglycerides and Impaired Enzyme Activity J. Biol. Chem., May 26, 1995; 270(21): 12518 - 12525. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. S. Cruz, G. Kwon, C. A. Marshall, M. L. McDaniel, and C. F. Semenkovich Glucose and Insulin Stimulate Heparin-releasable Lipoprotein Lipase Activity in Mouse Islets and INS-1 Cells. A POTENTIAL LINK BETWEEN INSULIN RESISTANCE AND beta -CELL DYSFUNCTION J. Biol. Chem., April 6, 2001; 276(15): 12162 - 12168. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| All ASBMB Journals | Journal of Biological Chemistry |
| Molecular and Cellular Proteomics | ASBMB Today |
