Journal of Lipid Research, Vol 30, 673-679, Copyright © 1989 by Lipid Research, Inc.
Effects of monosulfate esters of taurochenodeoxycholate on bile flow and biliary lipids in hamsters
RD Stevens, L Lack, RH Collins, WC Meyers Jr and PG Killenberg
Department of Medicine, Duke University Medical Center, Durham, NC 27710.
The effect of the 3 alpha- and 7 alpha-monosulfate esters of
taurochenodeoxycholate on bile flow and biliary lipids was compared to the
effect of unsulfated taurochenodeoxycholate. Test bile salts were infused
directly into the portal circulation through a catheter introduced into the
splenic pulp. Recovery of unsulfated and sulfated bile salts was complete;
no biotransformation of any of the administered compounds was noted.
Equivalent choleresis was noted in response to administration of each of
the test bile salts. Of particular interest, the biliary cholesterol and
phospholipid content was tightly linked to biliary bile salt monosulfates;
the slope of the line describing the relationship between bile salts and
lipids was similar to that for the unsulfated bile salt. The critical
micellar concentration of the 3 alpha- and 7 alpha-monosulfate esters was
19 mM and 18 mM, respectively. Sulfation of taurochenodeoxycholate,
therefore, does not impair its bile secretory function. Despite a higher
critical micellar concentration, biliary lipid excretion with monosulfate
esters is equivalent to that seen with unsulfated bile salt. The role of
hydrophobic/hydrophilic balance in the promotion of biliary lipid excretion
may need to be redefined.
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