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Journal of Lipid Research, Vol 30, 1065-1077, Copyright © 1989 by Lipid Research, Inc.
CR Pullinger, JD North, BB Teng, VA Rifici, AE Ronhild de Brito and J Scott
The objective of this study was to establish conditions whereby apoB
secreted from HepG2 cells could be regulated over a wide range, and to
determine whether changes of output were correlated with the level of apoB
mRNA. The presence of oleate (complexed to 3% albumin at a molar ratio of
1.7:1) resulted in a 3.5-fold stimulation of apoB secretion that was
apparent after only 3 h. Insulin halved the rate of apoB output and the
inhibition was detectable within the physiological insulin range, but was
not apparent until 12-16 h. Albumin in the culture medium had a
dose-dependent inhibitory effect on apoB production. Overall, apoB
secretion from HepG2 cells was modulated over a 7-fold range. However, when
apoB mRNA was assayed by slot-blot hybridization, no change was detectable
under any of the conditions that modulated apoB output. Quantitative
solution hybridization was used to confirm that oleate did not affect the
level of apoB mRNA. Kinetic analysis of the decay of [3H]uridine-labeled
apoB mRNA showed that the half-life of apoB mRNA was 16 h. We conclude from
these studies that the apoB gene is constitutively expressed in HepG2 cells
and that the mechanism of acute regulation of apoB production by these
cells must involve co- or post-translational processes.
ARTICLES
The apolipoprotein B gene is constitutively expressed in HepG2 cells: regulation of secretion by oleic acid, albumin, and insulin, and measurement of the mRNA half-life
Division of Molecular Medicine, MRC Clinical Research Centre, Harrow, United Kingdom.
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T. J. Aitman, I. F. Godsland, B. Farren, D. Crook, H. J. Wong, and J. Scott Defects of Insulin Action on Fatty Acid and Carbohydrate Metabolism in Familial Combined Hyperlipidemia Arterioscler Thromb Vasc Biol, April 1, 1997; 17(4): 748 - 754. [Abstract] [Full Text]
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S. L. Selby and Z. Yao Level of Apolipoprotein B mRNA Has an Important Effect on the Synthesis and Secretion of Apolipoprotein B–Containing Lipoproteins : Studies on Transfected Hepatoma Cell Lines Expressing Recombinant Human Apolipoprotein B Arterioscler Thromb Vasc Biol, November 1, 1995; 15(11): 1900 - 1910. [Abstract] [Full Text]
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C.-N. Wang, R. S. McLeod, Z. Yao, and D. N. Brindley Effects of Dexamethasone on the Synthesis, Degradation, and Secretion of Apolipoprotein B in Cultured Rat Hepatocytes Arterioscler Thromb Vasc Biol, September 1, 1995; 15(9): 1481 - 1491. [Abstract] [Full Text]
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A. E. Rusiol and J. E. Vance Inhibition of Secretion of Truncated Apolipoproteins B by Monomethylethanolamine Is Independent of the Length of the Apolipoprotein J. Biol. Chem., June 2, 1995; 270(22): 13318 - 13325. [Abstract] [Full Text] [PDF]
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 M Douaire, B Belloir, J. Guillemot, J. Fraslin, P Langlois, and J Mallard Lipogenic enzyme and apoprotein messenger RNAs in long-term primary culture of chicken hepatocytes J. Cell Sci., January 3, 1993; 104(3): 713 - 718. [Abstract] [PDF]
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M. Pan, J.-s. Liang, E. A. Fisher, and H. N. Ginsberg Inhibition of Translocation of Nascent Apolipoprotein B across the Endoplasmic Reticulum Membrane Is Associated with Selective Inhibition of the Synthesis of Apolipoprotein B J. Biol. Chem., August 25, 2000; 275(35): 27399 - 27405. [Abstract] [Full Text] [PDF]
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D. K. Spady, M. N. Willard, and R. S. Meidell Role of Acyl-Coenzyme A:Cholesterol Acyltransferase-1 in the Control of Hepatic Very Low Density Lipoprotein Secretion and Low Density Lipoprotein Receptor Expression in the Mouse and Hamster J. Biol. Chem., August 25, 2000; 275(35): 27005 - 27012. [Abstract] [Full Text] [PDF]
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