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Journal of Lipid Research, Vol 30, 1137-1145, Copyright © 1989 by Lipid Research, Inc.
B Staels, J Auwerx, L Chan, A van Tol, M Rosseneu and G Verhoeven
The influence of development and ethinylestradiol (EE) on apolipoprotein
(apo) A-I, A-II, and E mRNA in rat liver and intestine was studied by dot
blot hybridization and Northern blot analysis. ApoA- I mRNA levels were
maximal in the perinatal period and declined after day 15. An opposite
trend was noted for the apoA-II mRNA levels, whereas apoE mRNA remained
fairly constant. Liver apoA-I mRNA levels increased after ovariectomy
(OVX). A further rise was observed when EE was given at 2000
micrograms/day. When the influence of OVX and EE was controlled for food
intake by pair-feeding, OVX still increased hepatic apoA-I mRNA. The rise
in liver apoA-I mRNA after EE, however, was no longer significant. Under
the same conditions OVX slightly increased intestinal apoA-I mRNA. EE (2000
micrograms/day) decreased intestinal apoA-I mRNA to 80% of the pair-fed
controls. Liver apoA-II mRNA levels did not change after OVX when the
animals were fed ad libitum, but decreased slightly when the rats were
pair-fed. EE caused a dose- dependent decrease in liver apoA-II mRNA,
irrespective of food intake. None of these treatments caused any change in
liver apoE mRNA levels. Serum apoA-I levels increased upon OVX, while serum
apoE did not change. EE provoked a dose-dependent decrease of both
apolipoproteins in serum. In conclusion: 1) Changes in food intake play an
important role in the in vivo effects of estrogens on apolipoprotein mRNA
levels. 2) The stimulatory effect of OVX on hepatic apoA-I mRNA as well as
the inhibitory effect of EE on hepatic apoA-II mRNA are independent of food
intake.(ABSTRACT TRUNCATED AT 250 WORDS)
ARTICLES
Influence of development, estrogens, and food intake on apolipoprotein A-I, A-II, and E mRNA in rat liver and intestine
Laboratorium voor Experimentele Geneeskunde en Endocrinologie, Gasthuisberg, Katholieke Universiteit Leuven, Belgium.
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