Journal of Lipid Research, Vol 31, 131-135, Copyright © 1990 by Lipid Research, Inc.
Highly polymorphic apolipoprotein A-IV locus in the baboon
RE Ferrell, B Sepehrnia, MI Kamboh and JL VandeBerg
Department of Human Genetics, Graduate School of Public Health, University of Pittsburgh, PA 15261.
Apolipoprotein A-IV is found in mesenteric lymph chylomicrons, very low
density lipoprotein particles, high density lipoprotein particles, and in
the lipoprotein-free fraction of plasma. Apolipoprotein A-IV is polymorphic
in a variety of species including human, dog, and horse. Efforts to
estimate the impact of apolipoprotein A-IV structural variation on
quantitative lipid levels in humans have been limited by the low frequency
of the less common alleles. In the baboon, Papio hamadryas anubis, we have
found apolipoprotein A-IV to be highly variable at the protein level with
five alleles appearing at polymorphic frequency. We have confirmed the
autosomal codominant inheritance of these five alleles in pedigreed
baboons. The baboon has been shown to be a suitable animal model for the
study of atherosclerosis, and the existence of a common, multi-allele
apolipoprotein A-IV polymorphism in the baboon may be useful in elucidating
the role of apolipoprotein A-IV in lipid metabolism.
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