Journal of Lipid Research, Vol 31, 2141-2147, Copyright © 1990 by Lipid Research, Inc.
Effects of dietary monounsaturated fatty acids on plasma lipids in humans
NW Chang and PC Huang
Department of Biochemistry, College of Medicine, National Taiwan University, Taipei, R.O.C.
In order to test whether monounsaturated fatty acids (MUFA, M) would lower
plasma cholesterol and/or triglycerides (TG), 14 young men were studied in
a metabolism ward. They were given two experimental diets with the same P/S
ratio (P: polyunsaturated; S:saturated fatty acids) but different P + M/S
ratios in composition of dietary fatty acids. Six men were in experiment I.
In two groups of three, each group was given either the high or the low P +
M/S ratio diet for 6 weeks. In experiment II, two groups of four men were
subjected to a 3-week cross- over feeding trial (total of 6 weeks). We
found in the crossover study that when the dietary P/S ratio was fixed at
1.0, those subjects given a diet with the higher P + M/S ratio of 4.5
showed significantly higher plasma total TG, very low density lipoprotein
(VLDL)-TG, low density lipoprotein (LDL)-TG, and LDL-cholesterol than when
given a diet with a lower P + M/S ratio of 1.5. Plasma total cholesterol,
apoprotein A-I, and apoprotein B-100 were not significantly different
between the two dietary periods. Plasma fatty acid patterns showed a
significantly higher plasma MUFA level during the period of a higher P +
M/S diet. In contrast to some recent reports, our studies indicate that a
large amount of dietary MUFA may raise some fractions of plasma lipids in
humans.
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