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Journal of Lipid Research, Vol 31, 2277-2284, Copyright © 1990 by Lipid Research, Inc.

ARTICLES

Functional characteristics of LDL particles derived from various LDL- apheresis techniques regarding LDL-drug-complex preparation

HW Schultis, H von Baeyer, H Neitzel and E Riedel
Freie Universitat Berlin, Institut fur Biochemie, FRG.

Low density lipoproteins (LDL) have the potential to serve as cell specific drug carriers. The LDL may be derived in large quantities from LDL-apheresis procedures. Therefore, LDL particles isolated from the waste of three types of LDL-apheresis were investigated concerning their functional integrity in cell transport tests. LDL particles obtained from dextran sulfate-apheresis (DSA) and heparin extracorporeal lipoprotein precipitation (HELP)-LDL-apheresis are capable of specific internalization into HepG2 cells via the apoB receptor pathway. DSA-LDL-apoB appears to be split into two fragments as judged by SDS gel-polyacrylamide gel electrophoresis without changing transport behavior. Membrane differential filtration (MDF)- and HELP-derived LDL particles showed parallel transport behavior and electrophoretic mobility. Acetylated LDL particles obtained from MDF- LDL-apheresis and from blood donation plasma were transported into P388- macrophages via the scavenger receptor pathway. The results confirm the use of LDL particles from LDL-apheresis as substrates for transformation into drug carriers.
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